Here, we show that decreased PNMT expression in the PHD2-deficient adrenal medulla reduces epinephrine synthesis, but systemic effects in these PHD2-deficient mice, such as enhanced EPO production, consequent RBC excess, and hypoglycemia, lead to enhanced secretion of this hormone from the adrenal gland (Fig. 6). This evidence concerns the gene EGLN1 and Hypoglycemia.