PDGF‐A and PDGF‐B, although rarely amplified in the human disease (Paugh et al., 2010; Puget et al., 2012; Zarghooni et al., 2010), consistently induce gliomas in mouse models (Hambardzumyan et al., 2009; Misuraca et al., 2015; Ozawa et al., 2014), even with no accompanying oncogenic mutations (Becher et al., 2010). This evidence concerns the gene PDGFB and central nervous system cancer.