Interestingly, we also noticed that the expression of Rack1 gene has been identified with significant upregulation in SHH, WNT, and Type 3 MB tumor samples, but reduction in Type 4 MB tissues based on gene profiling assay using Gene Expression Omnibus (GEO) DataSet (GSE124814) (Figure S4), which was in agreement with our immunostaining results (Figure 1). The gene discussed is SHH; the disease is neoplasm.