NPY and Abdominal obesity: Regarding body weight regulation, it has been showed that the rs16147 variant affected anthropometric, biochemical and inflammatory parameters in response to dietary interventions in overweight or obese subjects [70, 71], and its effect on central obesity and abdominal fat distribution were modified by dietary fat, suggesting that individuals carrying the C allele of the NPY rs16147 SNP might benefit more by taking a high-fat weight loss diet [72].