SAMHD1 and hematologic disorder: As SAMHD1 mutations were identified in several hematological malignancies, future efforts will be important to investigate whether SAMHD1 mutations can be found in other tumors of hematopoietic and lymphoid origin and to further pinpoint which exact amino acid residues in SAMHD1 are affected, in order to investigate their roles in SAMHD1’s diverse cellular functions.