Additionally, it was reported that SAMHD1 mRNA expression was downregulated in bone marrow samples of AML patients compared to a non-AML patient group [79]. SAMHD1 mRNA expression was not correlated with other downregulated apoptotic genes (BAD, BAX, BAK1, XIAP, and BIRC2) known to be relevant in AML pathogenesis. The gene discussed is BAX; the disease is acute myeloid leukemia.