By now, several studies also investigated the influence of SAMHD1 overexpression on proliferation in cancer-derived cell lines: In the cervical carcinoma-derived HeLa cells [15] and the lung cancer-derived cell line A549 [81], SAMHD1 overexpression led to reduced cell proliferation [15, 81] and a decrease in cellular dNTP levels [81]. This evidence concerns the gene SAMHD1 and lung cancer.