Underscoring the role of SAMHD1 mutations in CLL, a patient carrying a homozygous germ-line mutation in SAMHD1 (c.1609-1G > C) was described in a subsequent study who was diagnosed with CLL at only 24 years of age — with no other acquired mutations or chromosomal lesions detectable known to be recurrently found in CLL [15]. This evidence concerns the gene SAMHD1 and B-cell chronic lymphocytic leukemia.