Rothenburger et al. were able to show specific differences in SAMHD1 mRNA expression between T- and B-ALL: In cell lines derived from T-ALL, SAMHD1 mRNA levels were significantly reduced compared to cell lines with B-ALL origin; the same mRNA expression pattern could also be detected in T- versus B-ALL blasts from 306 ALL patients [76]. The gene discussed is SAMHD1; the disease is acute lymphoblastic leukemia.