Additionally, it was reported that SAMHD1 mRNA expression was downregulated in bone marrow samples of AML patients compared to a non-AML patient group [79]. SAMHD1 mRNA expression was not correlated with other downregulated apoptotic genes (BAD, BAX, BAK1, XIAP, and BIRC2) known to be relevant in AML pathogenesis. This evidence concerns the gene BAK1 and acute myeloid leukemia.