CRISPR/Cas9-mediated knock-out (KO) of SAMHD1 in monocytic, AML-derived THP-1 cells resulted in increased cellular dNTP levels and an enrichment in G1/G0 phase-cells, while a reduction only in the G2/M population occurred [10]. The gene discussed is SAMHD1; the disease is acute myeloid leukemia.