After adjusting for age, sex, alcohol consumption status, status of ever smoking, level of education, physical exercise, prediabetes, family history of CVD, DBP, body mass index, serum concentrations of total cholesterol, high-density lipoproteins-C, glucose, uric acid and C-reactive protein, and eGFR, the cubic spline interpolation revealed that the relationship between different levels of baseline SBPs values within the normal range and the CVD risk showed a U-shaped curve, with the lowest point corresponding to a baseline SBP of 110 mmHg (Fig. 1). Here, CRP is linked to prediabetes syndrome.