We tested association of expression of eight genes from the four top-ranked DEGs among APOE ɛ2/ɛ3 subjects (Table 1) and the top-ranked genes in the ε2/ε3-AD network (Supplementary Fig. 9) with immunoassay measures of pTau181/tTau ratio, pTau231/tTau ratio, Aβ42/Aβ40 ratio, and postsynaptic density protein 95 (PSD95) as well as with levels of C4A and C4B proteins in FHS/BUADC brain tissue (Supplementary Table 13). The gene discussed is C4A; the disease is Alzheimer disease.