Our results elucidated significant higher levels of TMP, CD138+MP, T cell subsets, PD1 expressed on T cells in active MM patients compared with controls, also there were significant positive correlations between PMP and PD1+CD4+T cells, CD138+MP and CD8, and PD1+CD8+T cells and all of the followings LDH, M protein, BM plasma level, and β2 microglobulin, furthermore, there were significantly elevated levels of PMP, CD138MP, PD1, CD8+T cells in patients who did not achieve CR with specific cutoff values as mentioned in Table 6. The gene discussed is HLA-G; the disease is Miyoshi myopathy.