In one study, MPs from irradiated breast carcinoma could express high levels of immunosuppressive proteins compared with unirradiated cells and modulate immune evasion partially by expression of PD-L1 with enhanced tumor growth; the study suggested that PD-L1 and MPs could be a possible biomarker to identify breast cancer patients who were likely benefited from radiotherapy and immunotherapy40. The gene discussed is CD274; the disease is neoplasm.