In addition, the efficient rupture of the strong interaction stablished between SARS-CoV-2 RBD and human ACE2 protein has been proposed to require the high-binding affinity antibodies toward multiples sites of RBD (at least two molecular epitopes) which highlights the importance of functional affinity in blockage SARS-CoV-2 infection14. This evidence concerns the gene ACE2 and COVID-19.