To confirm whether Dectin3 promotes FoxO1-mediated MDSC accumulation and abnormal immunomodulatory function in vivo, FoxO1-high-expressed adenovirus (0.2 mL of 1 × 1011) and 0.2 mL of empty adenovirus were injected into WT mice with lupus intravenously (Fig. 3K, left). This evidence concerns the gene CLEC4D and systemic lupus erythematosus.