To further determine the molecular mechanism of regulating the expression of OLR1 on Dectin3-deficient M-MDSCs, the expression of FoxO1 significantly increased in M-MDSCs of Dectin3−/− mice with lupus compared with WT mice with lupus (Fig. 6D, E). The gene discussed is CLEC4D; the disease is systemic lupus erythematosus.