To further confirm whether Dectin3 promoted lupus progression via inhibiting FoxO1 expression, FoxO1-high-expression adenovirus (0.2 mL of 1 × 1011) and 0.2 mL of empty adenovirus were injected into WT mice with lupus intravenously (Fig. 3K, left). This evidence concerns the gene CLEC4D and systemic lupus erythematosus.