CD4 and systemic lupus erythematosus: LOX-1+ M-MDSCs promoted the accumulation of Th17 cells and inhibited the differentiation of Treg cells, LOX-1+ M-MDSCs, and LOX-1− M-MDSCs from mice with lupus were co-cultured with CD4+ T cells from normal mice in different conditional media (Fig. 7A–C).