The M-MDSCs in the spleens of different groups of mice with lupus were further sorted and enriched, revealing that the apoptosis level of M-MDSCs after knocking down FoxO1 significantly decreased, and the increase in the number of inflammatory Th17 cells was promoted in Dectin3−/− lupus mice. The gene discussed is FOXO1; the disease is systemic lupus erythematosus.