Given that there is evidence of an inadequate type I interferon response in COVID-19 (6, 10), that the sera from COVID-19 (+) patients had less IFNβ than COVID-19 (−) ICU patients, and that our previous work has shown that IFNβ up-regulates Setdb2 during wound repair (22), we hypothesized that this pathway may be relevant in coronavirus infection. This evidence concerns the gene SETDB2 and COVID-19.