SETDB2 and infection: In vitro BMDMs, as well as ex vivo infected Mφs and in vivo isolated Mφs, from wild-type (WT) C57BL/6 mice all demonstrated decreased Setdb2 expression in response to MHV-A59 infection compared to uninfected controls (Fig. 2 C–E), and further analysis of infected BMDMs demonstrated decreased SETDB2 protein with infection (Fig. 2 F and G).