Here, we showed that ALS mice receiving human bone marrow endothelial progenitor cells (hBM-EPCs) versus hBM34+ cells substantially increased tight junction protein levels, capillary pericyte coverage, basement membrane laminin immunoexpressions, and endothelial cytoskeletal filamentous actin (F-actin) fluorescent expressions. The gene discussed is LAMB2; the disease is amyotrophic lateral sclerosis.