The fusion transcripts in CBF AML (RUNX1-RUNX1T1 or CBFB-MYH11) resulting from t(8;21) or inv(16)/t(16;16), respectively, are readily detected by RT-qPCR at a sensitivity ranging from 10–4 to 10–6 [15]. Here, RUNX1 is linked to acute myeloid leukemia.