SOS2 and neoplasm: After treatment with sulfarotene at 0, 0.22 and 2.2 mg/kg by i.v. injection once every 2 days for 21 days, both the volume and weight of tumor nodes of high SOS2 expressors were markedly suppressed by both the low and high dose treatments compared to that of the low SOS2 expressors and the DMSO control group (Fig. 8d-f).