Analyses of SOS2 expression by qPCR from a cohort of 45 patients, as well as by IHC from a cohort of 237 HCC patients in which 127 had metastasis, revealed that the levels of SOS2 in both the primary and the metastatic tumor foci were higher than in the paired peritumor tissues (Figure S8e-h). This evidence concerns the gene SOS2 and hepatocellular carcinoma.