MAPK1 and cancer: In addition, overexpression of miR-140-5p could inhibit proliferation, migration, and invasion and promote apoptosis in cancer by downregulating MAPK1, TRIM28, and YES1, further regulating levels of cleaved caspase-3, Bcl-2, and Bax, and blocking nuclear transport and Wnt/β-catenin signaling [19, 20, 25, 36, 37].