TLR4 and intestinal neoplasm: However, a conflicting study conducted by Li et al. [56] showed that the constitutive activation of TLR4 in intestinal epithelium resulted in an elevation of intestinal tumor cell apoptosis levels and a reduction of intestinal tumor burden in the ApcMin/+ mice, indicating that persistent epithelial activation of TLR4 might play a role in inhibiting intestine tumorigenesis by enhancing apoptotic signals.