The CANDLE trial in clinically stable patients with T2D and documented chronic HF (CHF) was designed primarily to assess the clinical safety and efficacy of 24 weeks of add-on canagliflozin treatment, relative to glimepiride, based on the effects on N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration [17, 18]. This evidence concerns the gene NPPB and type 2 diabetes mellitus.