CD8A and cholestasis: Histopathology revealed acute liver cell necrosis with canalicular cholestasis but also a subtotal porto-portal liver cirrhosis with reactive ductular proliferation (Fig. 2H–J) accompanied by a moderate T-cell rich portal inflammatory infiltrate that was partially spreading to the hepatic interface and mainly consisting of CD8 + cytotoxic T-cells (CD8/CD4 ratio 2:1).