Compared with the COPD rats treated with NAC + oe-VWF + sh-NC, expression of p38 MAPK and the extent of p38 MAPK phosphorylation elevated, and VWF expression showed no obvious difference in lung tissues of COPD rats treated with NAC + oe-VWF + sh-p38 MAPK (Fig. 6A). The gene discussed is VWF; the disease is chronic obstructive pulmonary disease.