KRAS and infection: The drug resistance amino acid substitutions most commonly observed in patients with HCV genotype 6 infections are 41K/R (a change to K or R at position 41), 43C, 56H, 156S/T/V, and 168A/E/G/N/H/V/Y in NS3, 24H, 28M/V, 31I/M/V, 32A/L/Q/R/S/Del, 58A/G/H/N/S, 92T/K, and 93A/H/N/S in NS5A, and 282T/G/R in NS5B (14, –, 16).