LDLR and fungal infectious disease: Inflammation induced by thioglycolate or bacterial or fungal infection leads to an increase in this hybrid population in mouse models of tissue inflammation, and these cells have also been found in human tumors.47, 48, 49 Our data extend these observations to show that bleomycin also drives accumulation and differentiation of these cells, an effect that we showed to be significantly blunted by LDLR.