Therefore, we searched ChIP-sequence data in the Encyclopedia of DNA Elements (ENCODE) project for binding signals of C/EBPβ and EGR-1 around the GLUT1 promoter region in HCT-116 cell (24), because it is a human colon cancer cell line that highly expresses GLUT1 (25). Here, CEBPB is linked to malignant colon neoplasm.