Purified CTLP that directly bind to GPIb from Bothrops caribbaeus venom [68] and BjV (GPIb-BP, [42]), without the participation of VWF, have been shown to induce thrombocytopenia when injected in animals, but experimental evidence must still be obtained showing they are important toxins to induce thrombocytopenia during B. jararaca envenomation. The gene discussed is VWF; the disease is Thrombocytopenia.