Although rarely diagnosed, some patients bitten by B. jararaca also manifest thrombotic microangiopathy [73,74], but their ADAMTS13 levels were normal as well as in others bitten by other snakes [75], indicating that venom toxins are directly involved in the phenomena of activation of coagulation, endothelial injury, and red blood cell lysis and poikilocytosis. This evidence concerns the gene ADAMTS13 and Genetic thrombotic microangiopathy.