ADAMTS13 and thrombotic microangiopathy: Although rarely diagnosed, some patients bitten by B. jararaca also manifest thrombotic microangiopathy [73,74], but their ADAMTS13 levels were normal as well as in others bitten by other snakes [75], indicating that venom toxins are directly involved in the phenomena of activation of coagulation, endothelial injury, and red blood cell lysis and poikilocytosis.