Once purified botrocetin induces thrombocytopenia by a mechanism that is dependent on VWF, we investigated herein, using two experimental models, whether botrocetin and VWF are involved in BjV-induced thrombocytopenia, as the comprehension of these pathophysiological events may lead to better treatments of hemostatic disorders of patients bitten by B. jararaca snakes. The gene discussed is VWF; the disease is Thrombocytopenia.