VWF and von Willebrand disease (hereditary or acquired): Purified 2-chain botrocetin causes the rapid consumption of circulating platelets and plasma VWF when injected i.v. in high doses in normal rats, pigs and dogs, but is innocuous to induce thrombocytopenia in VWD animals, showing that the thrombocytopenia was dependent on basal VWF levels in circulation [51–53].