AKT1 and neoplasm: Platelet-derived microparticles (P-MPs), such as vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP), epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), can induce the activation of MAPK and AKT signaling pathways in tumor cells, so as to stimulate the over expression of proteins required for tumor cell proliferation [42].