RHBDF1 and cancer: Nevertheless, the iRhoms RHBDF1 and RHBDF2 have been implicated in neurological disorders including Alzheimer’s and Parkinson’s diseases, as well as in cancer, inflammation, and skin diseases (Jager et al. 2014; Raj et al. 2018; Hosur et al. 2014; Hosur et al. 2018; Yan et al. 2008; Zhou et al. 2014; Zou et al. 2009; Blaydon et al. 2012; Young 2019).