EZH2 and colorectal carcinoma: Wang et al. reported that lncRNA SATB2-AS1 inhibits the invasion and metastasis of CRC by suppressing the Snail transcription and epithelial-mesenchymal transformation (EMT) through SATB2 [26]; Zhuang et al. demonstrated that lncRNA MALAT1 sponges miR-106b-5p to modulate SLAIN2 and enhances microtubule mobility to facilitate the invasion and metastasis of CRC cells [27]; Shi et al. indicated that by acting as a competitive endogenous RNA of miR-144, lncRNA znfx1-as1 regulates EZH2 expression to promote tumor progression and metastasis of CRC cells [28].