Furthermore, the expression levels of other M1 macrophage-related cytokines (iNOS, IL-1β, TNF-α, CXCL10, and CCR7) were remarkably lower, while those of other M2 macrophage-related cytokines (IL-10, CCL1, CCL2, CCL17, and Arg-1) were significantly higher in the RMDMs of HSP rats compared to normal rats (Figure 2(A,B)), which were consistent the above findings. This evidence concerns the gene NOS2 and hereditary spastic paraplegia.