To determine whether the actions of DDR2 in CAFs influenced tumor cell metastatic properties in vivo, we co-injected mouse CAFs of Ddr2+/+ or Ddr2−/− genotype alongside WT primary PyMT tumor cells (Ddr2+/+) into the tail vein of syngeneic FVB/N female mice and measured lung colonization after 7 days. Here, DDR2 is linked to neoplasm.