To determine the importance of the intracellular tyrosine kinase activity and tyrosine kinase domain of DDR2 in supporting breast tumor cell invasion, migration and metastasis, we depleted DDR2 using shRNA treatment in a set of human (BT549, Hs578 T and MDA-MB-231) and mouse (4T1) breast tumor cell lines. The gene discussed is DDR2; the disease is breast neoplasm.