These results also concur with those of a previous report showing that the sarcomatoid component of lung cancer was more immunoreactive for fascin.[32] We postulate that the association between fascin-positive staining in cancer cells and a poorer prognosis may be a confounding factor, reflecting the fact that a poor or sarcomatoid morphology usually leads to a poorer prognosis. This evidence concerns the gene FSCN1 and lung cancer.