FSCN1 and breast cancer: To the best of our knowledge, our data, for the first time, has revealed that CAFs can be immunostained for fascin, presumably associated with their extremely large filopodia and high rate of cellular migration.[10,11] Since it has been reported that CAFs promote tumor progression, invasion, metastasis, and chemotherapy resistance, and are associated with a poor prognosis in pancreatic and breast cancers,[8,27–29] the expression of fascin in CAFs is likely to be associated with these functions.