In previous studies on its effect on corneal endothelial cells, BUN was significantly higher in DM patients than in the control group, but it did not affect the corneal endothelium, and other study reported that the urinary albumin-creatinine ratio was correlated with ECD.[36,37] Regarding renal function and corneal endothelial cell status, Ohguro et al[38] reported that polymegethism and pleomorphism were increased in patients with chronic renal failure. This evidence concerns the gene ALB and chronic kidney disease.