For example, in a study of 1919 patients in Wuhan, patients with acute cardiac injury, defined as serum hs-cTnI above the 99th percentile upper reference limit, had an odds ratio of 80.07 for in-hospital mortality, and nonsurvivors had significantly higher levels of hs-cTnI (nearly tenfold) than survivors [66]. This evidence concerns the gene TNNI3 and injury.