At patient level, 62.5% of the I-PET- and EoT-PET-positive MYC + DLBCL patients had higher MTV at EoT than at I-PET, whereas relatively fewer (38.5%, p = 0.140) of the MYC- DLBCL patients with PET-positive results showed higher MTV at EoT compared to I-PET. Here, MYC is linked to diffuse large B-cell lymphoma.