Approximately 30% of MYC + large B-cell lymphoma patients have a MYC rearrangement (single hit (SH) DLBCL), whereas in 70% MYC rearrangements are detected together with BCL2 and/or BCL6 rearrangements (double hit (DH) or triple hit (TH) high grade B-cell lymphomas) [4]. Here, BCL2 is linked to diffuse large B-cell lymphoma.