Regulating APP expression may have beneficial effects in MND since genetic deletion of APP (APP−/−) in the SOD1-G93A mice significantly slowed disease progression and promoted motor neuron survival, whilst the neuromuscular junction (NMJ) innervations in SOD1-G37R:APP−/− mice showed reduced denervation and improved muscle contractility [22]. This evidence concerns the gene SOD1 and mild neurocognitive disorder.