Although sex-specific differences have been identified in both the SOD1-G37R [90] and the SOD1-G93A mouse models for MND [15, 16, 18], our new findings identified sex-dependent effect associated with APP and APLP2 expression levels which may be linked to their neuroprotective properties in neurodegenerative disorders. The gene discussed is APLP2; the disease is mild neurocognitive disorder.