The biochemical changes at the NMJs whereby significant improvement and reduction in denervation and muscle atrophy in the female SOD1-G37R:APLP2−/− mouse compared to SOD1-G37R:APLP2 wild-type littermates were observed, suggest APLP2 may be directly involved with NMJ denervation in MND. This evidence concerns the gene SOD1 and mild neurocognitive disorder.