IGF1 and Insulin resistance: The Janus kinase (JAK)/STAT3 pathway as well as the activation of STAT3 through AKT kinase and mTOR are the important insulin/IGF-1-stimulated, STAT3-mediated signaling pathways which are able to control immunosuppression, immunosenescence, and insulin resistance (Figs. 1, 2, 3).