In addition to VEGF, activated Ang2 signaling also plays a significant role in promoting tumor immunosuppression: for one thing, Ang2 facilitates the recruitment of MDSCs (myeloid-derived suppressor cells) (226), Treg cells (227), and TIE2-expressing monocytes via upregulating adhesion molecules between leukocytes and ECs (228); for another, Ang2 limits the anticancer activity of monocytes by inhibiting the secretion of TNF. This evidence concerns the gene TNF and neoplasm.