AKT1 and central nervous system cancer: Interaction of prominin-1 with histone deacetylase 6 was shown to stabilize β-catenin in a colon carcinoma cell line (15), and prominin-1 was suggested to mediate activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway in glioma stem cells by its binding to p85 regulatory subunit of PI3K (16).