In addition, colon carcinoma CT26 murine syngeneic tumors that exhibit high immunogenicity and the mesenchymal-like phenotype are susceptible to immunotherapy with anti-PD-L1 mIgG2, an IgG subclass with the highest affinity for activating FcγR typically expressed by TAMs. The gene discussed is FCGR2A; the disease is colon carcinoma.