Remarkably, fourth-generation CAR-T-cells (TRUCKs), engineered with anti-carcinoembryonic antigen (CEA, CD66) antibody single-chain peptide and modified to secrete inducible IL-12 (IL-12), upon engaging tumor cells, reprogram TAMs recruited into the tumors to be tumoricidal cells that cooperate with CAR-T-cells for tumor regression and cancer cell elimination (Figure 3(a)) [87, 88]. The gene discussed is CEACAM5; the disease is neoplasm.