Similarly, conditioned media from human pancreatic ductal adenocarcinoma (PDAC) cell lines induce in vitro TAM-like cells with upregulated HK2, glucose-6-phosphate isomerase (GPI), aldolase A (ALDOA), triosephosphate isomerase 1 (TPI1), and phosphoglycerate kinase 1 (PGK1) transcript expression and increased L-lactate production by expression of lactate dehydrogenase A (LDHA) [32]. The gene discussed is TPI1; the disease is pancreatic ductal adenocarcinoma.