Among those patients screened, 64.8% developed an AKI at any time during their ICU admission and 18.3% needed RRT (Table 3). The development of AKI at any time during the admission was associated with an elevated peak D-dimer (4.6 mg/L vs 2.3 mg/L, p=0.03), thrombocytopenia (platelets nadir: 134 × 109/L vs 176 × 109/L, p=0.007) vWF/ADAMTS13 ratio (10.3 vs 5.3, p=0.02) and a trend towards lower ADAMTS13 activity (51.6 IU/dL vs 66.1 IU/dL, p=0.13; Figure 3 and Tables 4-7). This evidence concerns the gene VWF and acute kidney injury.