VWF and COVID-19: In this small, single-centre, cross-sectional study of critically ill COVID-19 patients, we have found significant alterations in coagulation profiles with associated indices of increased severity of illness and clinical outcomes. Compared to the locally derived and manufacturers ranges, we found elevated levels of factor VIII and vWF antigen with lower ADAMTS13 activity in this group. Both admission and peak D-dimer levels are elevated from standard ranges.