The results showed that PAM could significantly inhibit the amount and activity of ERK (p=2.56E-5 for total protein, p=4.94E-4 for ERK phosphorylation), p38 (p=8.03E-6 for total protein, p=0.0028 for p38 phosphorylation) and p65 (p=5.12E-4 for total protein, p=1.01E-4 for p65 phosphorylation) in prostate cancer cells; the phosphorylation level of JNK was significantly increased (p=2.52E-5) while its total protein level was reduced with statistical significance (p=1.81E-4) in DU145 cancer cells. Here, MAPK8 is linked to Familial prostate cancer.