In order to further explore the mechanism of CAP-induced cancer cell death, we examined the total level and phosphorylation status of c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase (ERK), and p38, each representing one MAPK pathway, as well as p65, the most common form of NF-Kb, in PNT1A and DU145 cells after PAM treatment for 8 h (Figure 7). Here, MAPK8 is linked to cancer.