AR and Familial prostate cancer: Here, in this study, we demonstrated that PAM conferred both anti-proliferative and anti-migrative abilities in AR-independent prostate cancer cells DU145 without significantly affecting normal prostate cells; and reported that halted proliferation and migration in response to PAM treatment might be attributable to apoptosis and G0/G1 cell cycle arrest that were specifically triggered in prostate cancer cells after PAM treatment.