SHMT2 and hepatocellular carcinoma: Moreover, an increasing number of studies have demonstrated that SHMT2 is overexpressed in the tissues of hepatocellular and intrahepatic biliary carcinoma patients and that a higher SHMT2 level is clinically related to a worse survival outcome than a lower level of SHMT2, suggesting that SHMT2 could be used as a potential prognostic biomarker in HCC 20, 21.