We demonstrate for the first time that incubating KLM-1 pancreatic cancer cells with oxLDL shifts the energy balance towards a more glycolytic phenotype, which is supported by oxLDL-induced stabilization of hypoxia-inducible factor 1-alpha (HIF-1α), a master regulator of glycolysis. The gene discussed is HIF1A; the disease is pancreatic neoplasm.