STC2 was over-expressed in tumors such as colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), glioblastoma multiforme (GBM) and HNSC, etc. and under-expressed in acute myeloid leukemia (LAML) and skin cutaneous melanoma (SKCM) (Figure S2). This evidence concerns the gene STC2 and cutaneous melanoma.