The results also showed that the high expression rate of TMEFF1 in the atypical endometrial hyperplasia group was significantly higher than that in the normal endometrium group, and lower than that in the malignant group, which demonstrates that the expression of TMEFF1 was related to the malignant progression of endometrial cancer, and can monitor the malignant transformation and prognosis in patients with atypical endometrial hyperplasia. This evidence concerns the gene TMEFF1 and endometrial cancer.