RIOK1 and AKT1 mRNA levels were significantly higher in glioma patient tissues compared to normal brain tissues (TCGA-GBMLGG and GTEx databases, Figure 1A), and their expression levels were significantly correlated (TCGA-GBMLGG databases, p<0.001, r=0.440, Figure 1B). The gene discussed is AKT1; the disease is glioma.