In addition, loss-of-function assays demonstrated that lncRNA-PVT1 inhibition suppressed the proliferation and invasion in glioma cells in vitro and reduced tumor growth in vivo. Then the regulatory relationship between lncRNA-PVT1 and miR-1207-3p was validated through bioinformatics analysis, luciferase reporter assay as well as FISH assay. This evidence concerns the gene PVT1 and glioma.