As shown in Table 2, the higher concentrations of COL1A1 were significantly correlated with the peripheral type tumor (P < 0.001), larger diameter of the tumor (P = 0.028), occurrence of lymph node metastases (P < 0.001) and distant metastases (P = 0.001), higher TNM stage (III, IV) (P = 0.049), and smoking (P < 0.001). The gene discussed is COL1A1; the disease is neoplasm.