Statistical analysis revealed that higher COL1A1 expression were significantly correlated with the peripheral type tumor (P = 0.001), larger diameter of the tumor (P = 0.009), occurrence of lymph node metastases (P = 0.009) and distant metastases (P < 0.001), higher TNM stage (III, IV) (P = 0.006), and smoking (P < 0.001) (Table 1). The gene discussed is COL1A1; the disease is neoplasm.