Previously, we reported that other copper compounds like Cas III-ia inhibits cell proliferation and induces apoptosis and autophagy in C6 rat glioma cells through the formation of ROS, followed by activation of JNK, phosphorylation of c-jun, and expression of Beclin 1, Atg 7, and Bax 16. The gene discussed is BECN1; the disease is central nervous system cancer.