On the other hand, it has been reported that when SNAIL expression is silenced in U87-MG and GBM05 glioblastoma-derived cell lines, the expression of vimentin is decreased, with the ensuing upregulation of E-cadherin and a decrease in proliferation, a retarded cell cycle, and impaired cell invasion/migration in vitro 47, 49. The gene discussed is VIM; the disease is glioblastoma.