MAPT and Alzheimer disease: Numerous articles have demonstrated that SAMP8 mice display advancing aging status and share common characteristics with the aged and AD patients, including age-related deteriorative cognition and behavioral alteration [4, 5], neuropathological phenotypes such as neuron loss and synaptic plasticity impairment [6, 7], hyperphosphorylation of tau forming neurofibrillary tangles [8], APP amyloidogenic processing [9], and other pathological features in age-related neurodegeneration [10].