F2 and liver cancer: Serum macrophage migration inhibitory factor (MIF), Golgi protein 73 (GP73), abnormal prothrombin (protein induced by vitamin K absence or antagonist-II, PIVKA-II), alpha-fetoprotein (AFP) and lentil lectin-reactive alpha-fetoprotein-L3 (AFP-L3), as detection indicators in clinical practices, have certain diagnostic value for the early diagnosis of primary liver cancer.2-4 There have been studies of using a single one for detection, as well as combining 2 or three for detection, but whether combining 5 to improve sensitivity, specificity, and accuracy remains to be studied.