MUC5AC and chronic purulent otitis media: Chronic Suppurative Otitis Media (CSOM) is a chronic middle ear inflammation commonly associated with ear discharge due to several factors such as overproduction of mucin, decrease pro-inflammatory responses and undiagnosed or untreated acute otitis media.1 Reported literature showed that patients with CSOM has to compromise the quality of life with other consequences of the disease such as tinnitus, vertigo, dizziness and even fever.2 The association between hearing loss in CSOM patients with depression, anxiety and stress was also observed in local population of Karachi.3