The study based on skin test and enzyme-linked immunoassay of the sample analysis conducted population shows that higher level of IgE in the patients’ samples indicates its role in CSOM.8 Therefore, present study may be helpful where no data or very few in CSOM adult patients is available in local population because IgE level may be one of the risk factors in CSOM.9 It was also observed that significant difference was present in IgE levels between untreated CSOM patients (G2) and treated patients with ciprofloxacin (G3) and co-amoxicillin (G4). Here, IGHE is linked to chronic purulent otitis media.