IGHE and chronic purulent otitis media: It is reported that several inflammation triggering agents which are also involved in infection like bacteria, protozoa or virus can stimulate the catabolism of tryptophan (5-HTP) of the chemicals which contribute in different infections3 including chronic condition of otitis media is Immunoglobulin E (IgE).4-6 However, there is no study found to prove association of serotonin (decreased levels) with CSOM.